[Specific cutaneous manifestations in adult Tcell leukemia/lymphoma]

Adult T cell leukemia/lymphoma [ATLL] is an aggresive malignancy which may occur in human T lymphotropic virus [HTLVl] infected persons. HTLV1 is endemic in Khorasan with prevalence of 2.3% in general population. Since specific cutaneous manifestations of lymphoma may occur in a significant number of patients, we studied ATLL patients in Mashhad In this descriptive study the demographic and clinical data of 23 patient suffering from ATLL who were admitted in hematology and dermatology departments of Ghaem Hospital, during 1995-2004 and had specific cutaneous lesions confirmed histopathologically with atypical lymphocytes in skin lesions, were recorded and analyzed. Eleven patients were male and 12 were female. The mean age of patients was 48.17 +/- 14.1 years. Birth places of over 85% of cases were north of Khorasan. The most common types of specific skin lesions were maculopapular rash in 11 cases [47.8%] and papular lesions in 4 cases [17.4%]. Other lesions included plaque, icthyosis like, erythroderma, tumor, and nodular lesions. In most of patients [56.5%] the skin lesions were generalized The most common type of specific skin lesions in ATLL was maculopapular rash especially with generalized distribution. Other types of specific skin lesions in order of frequency were papule, plaque, icthyosis like, nodule, tumor and erythroderma

Cutaneous manifestations of diabetes mellitus: a study from Lahore, Pakistan

To assess the spectrum of cutaneous changes in diabetes mellitus in Lahore, Pakistan. Design; Prospective clinical study with follow up of 4 months. Setting; Medical outdoor and indoor, Mayo Hospital, Lahore. Subjects: One hundred adult patients of any age and either sex suffering from diabetes mellitus. Main outcome measures: Cutaneous manifestations. Of 100 patients, skin changes were found in 96% of patients [P<0.00001]. The most frequent finding was the cutaneous infections [55%]. Other common findings included: tingling and burning of feet [45%], sweating disorders [26%], tartar deposits [24%], gingivitis [22%], diabetic dermopathy [18%], generalized pruritus [15%], localized pruritus [15%] and thickened skin [12%]. Less common manifestations were: nail disorders [11%], skin tags [10%], cherry angiomas [7%], vitiligo [5%], foot ulceration [5%] and burning mouth [5%] Rare features were: insulin complications [3%], xanthelasma palpebrarum [3%], amputation toe [3%], callus and fissures over feet [2%], syndrome of limited joint mobility and waxy skin [2%] and eruptive xanthomas [2%]. Conclusions: There is significantly increased prevalence of cutaneous manifestations in our diabetic patients [p<0.00001]

Dactilitis tuberculosa / tuberculosis dactilitis

Se presenta el caso de una lactante mayor de 19 meses, quien se presenta con lesiones de piel y deformidades ósea en huesos de manos y pies que comenzaron a los sites meses de vida, como concomitante el punto donde se le habia inoculado la BCG a los 15 días de vida nunca sanó, sino por el contrario se activó correspondiendo a su patología actual. Se encontró la presencia de BAAR en el contenido gástrico y en los ganglis y hubo exelente respuesta al tratamiento antituberculoso, con todo esto se hizo el diagnóstico de dactilitis tuberculosa secundaria a la administración de BCG, explicable por el fenómeno de Koch

Lesöes cutâneas da esquistossomose mansoni / Cutaneous manifestations of Schistosomiasis mansoni

É feita revisäo das lesöes dermatológicas que podem ocorrer nas esquistossomoses, especialmente na esquistossomose mansoni, doença de expressiva endemicidade no Brasil, somando aproximadamente 12 milhoes de doentes. Säo descritas as lesöes cutâneas recentes (fase pré-postural), tardias (fase pós-postural e de esquistossomose cutânea propriamente dita, buscando caracterizar sua etiopatogenia, quadro clínico-histopatológico e laboratorial, evoluçäo e tratamento. Säo analisadas as dificuldades de diagnóstico destas lesöes e os aspectos intrigantes da forma cutânea ectópica da esquistossomose mansoni, da qual a autora descreveu o primeiro paciente

Les manifestations cutanees du diabetique

Dermatological lesions are common in all diabetic types. They can result from degenerative or arteriopathic lesions. They can also be the result of antidiabetic treatment. The lesions aren't really specific but some are very suggestive. Our modest work illustrates the frequency [60%] and the diversity of these manifestations which are relative to the diabetic's age, additionnal diabetic complications, the degree of metabolic control as well as socio-economic factors. It's most important to emphasize the need for education concerning diabetes in an effort to enhance the patient's metabolic control as well as improve hygiene, especially with regard to feet care

Angeítis cutáneas: inmunofluorescencia directa y morfopatología de 23 casos / Cutaneous angeitis: morphology and direct immunofluorescence in 23 patients

We reviewed the finging in 23 patients with hystologically diagnosed cutaneous angeitis, bet-ween 1981 and 1985. There were 8 males and 15 females, with a mean age fo 43 years. Four hystological patterns were identified: leukocytoclastic angeitis in 9 (31%), lymphocytici angeitis in 8 (35%), capillaritis in 2 (9%) and minimal alterative angeitis in 4 (17%). Serum complement levels were normal in 56% and low in the remainder. fourteen patients (61%) showed positive direct immunofluorescence for complement fractions and different immunoglobulins in skin lesions. All cases with lymphocytic angeitis yelded a positive reaction as compared to only 66% in leucocytoclastic angeitis. No correlation was found between serum complement levels and histologic pattern of angelitis. The present results suggest that direct immunofluorescence in diseased skin is a more sensitive procedure for identifying active cutaneous angeitis

Manifestaçöes orocutâneas em doenças do trato digestivo / Orocutaneous manifestations in digestive tract disease

Säo brevemente revistas as numerosas condiçöes tegumentares que ocorrem em doenças gastrenterológicas. Algumas têm significado diagnóstico importante, enquanto outras chegam a merecer a qualificaçäo de "patognomônicas". O autor chama a atençäo para a importância de ectoscopia no diagnóstico acurado de condiçöes gastrenterológicas